FASTest® C. perfringens Toxin

The gram positive anaerobic bacterium Clostridium perfringens belongs to the physiological intestinal flora of many mammals and is facultative pathogenic. Inconvenient endogeneous (other basic diseases, diarrhoea pathogens, antibiotic therapies with massive reduction of intestinal flora etc.) and exogeneous (farming conditions, extreme changes of the food, stress etc.) factors can lead to an increased pathogenicity of C. perfringens. Next to its ability to form extremely infectious and stable spores, the formation of lethal toxins is crucial for its pathogenicity. The classification into the various types (A–E) is only due to the toxin formation.

These toxins can cause extremely variable (mild to lethal progression forms) failures of the intestinal water and electrolyte balance in the different species like goat, sheep (e. g. dysenteria of lambs: type B; pulpy kidney disease: type D), cattle (haemorrhagic enteritis: type A–E), foal (haemorrhagic necrotising enteritis: type A & C) and piglet (e. g. serous-catarrhal enteritis: type A, necrotising enteritis: type C).

In the dog, especially serotype A occurs, producing 2 main toxins (toxin Alpha [α] and a Clostridia enterotoxin [CPE]), rarer serotype B (toxin Beta [β]). Both C. perfringens and its CPE can be detected also in healthy dog’s feces. The CPE can be detected more often in dogs with diarrhoea compared to healthy dogs. CPE is more frequent in dogs with diarrhoea (haemorrhagic gastroenteritis, acute or chronic diarrhoea, enterotoxaemia) than in healthy dogs. For cats, to date reliable literature data concerning prevalence and clinical relevance are missing.

Only by detection of C. perfringens in the feces, a disease caused by Clostridia is not diagnosable. In a study in Switzerland, 54 % of the C. perfringens isolates showed a reduced sensitivity towards metronidazole or 18 % towards tetracycline. Because there is a general risk of resistance formation, it is recommended to identify the triggering pathogen in principle. By its high sensitivity and specificity, the use of FASTest® C. perfringens Toxin allows the veterinarian a rapid aetiological on-site diagnosis of a C. perfringens infection, the quick initiation of therapy as well as of necessary quarantine and prophylaxis measures.

• Test Principle :  Lateral flow
• Packaging :  10
• Pathogenic :  Clostridium perfringens